Rottlerin promotes apoptosis and autophagy in pancreatic stellate cells via AMPK activation
Results: Rottlerin at concentrations as low as 0.5 μM induced rapid (within 3 min) mitochondrial membrane depolarization associated with AMPK activation, as determined by a significant increase in phospho-AMPKα (Thr172) levels, an effect that persisted for at least 48 h. A marked inhibition of the...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-03, Vol.13 (2), p.e50-e50 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
| container_volume | 13 |
| creator | Lugea, A Javaherizadeh, P Hui, H Waldron, R.T Go, V.L.W Pandol, S.J |
| description | Results: Rottlerin at concentrations as low as 0.5 μM induced rapid (within 3 min) mitochondrial membrane depolarization associated with AMPK activation, as determined by a significant increase in phospho-AMPKα (Thr172) levels, an effect that persisted for at least 48 h. A marked inhibition of the Akt/mTOR pathway was indicated by reduced phosphorylation of Akt (Ser473) and the mTORC1 substrates p70 S6 kinase and 4EBP1. |
| doi_str_mv | 10.1016/j.pan.2012.12.230 |
| format | Article |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2013-03, Vol.13 (2), p.e50-e50 |
| issn | 1424-3903 1424-3911 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Apoptosis Autophagy Endocrinology & Metabolism Gastroenterology and Hepatology Phosphorylation |
| title | Rottlerin promotes apoptosis and autophagy in pancreatic stellate cells via AMPK activation |
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