Rottlerin promotes apoptosis and autophagy in pancreatic stellate cells via AMPK activation

Rottlerin promotes apoptosis and autophagy in pancreatic stellate cells via AMPK activation

Results: Rottlerin at concentrations as low as 0.5 μM induced rapid (within 3 min) mitochondrial membrane depolarization associated with AMPK activation, as determined by a significant increase in phospho-AMPKα (Thr172) levels, an effect that persisted for at least 48 h. A marked inhibition of the...

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Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-03, Vol.13 (2), p.e50-e50
Hauptverfasser: Lugea, A, Javaherizadeh, P, Hui, H, Waldron, R.T, Go, V.L.W, Pandol, S.J
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Autophagy
Endocrinology & Metabolism
Gastroenterology and Hepatology
Phosphorylation
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Zusammenfassung:Results: Rottlerin at concentrations as low as 0.5 μM induced rapid (within 3 min) mitochondrial membrane depolarization associated with AMPK activation, as determined by a significant increase in phospho-AMPKα (Thr172) levels, an effect that persisted for at least 48 h. A marked inhibition of the Akt/mTOR pathway was indicated by reduced phosphorylation of Akt (Ser473) and the mTORC1 substrates p70 S6 kinase and 4EBP1.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.230