Frontispiece: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT)

Molecular Recognition In their Full Paper on page 126 ff., G. Klebe, F. Diederich et al. describe a novel series of lin‐benzoguanines that target the polar ribose‐34 pocket of Z. mobilis TGT with a furanosyl moiety. The preparation involved a new cyclization strategy for the lin‐benzoguanine core an...

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Veröffentlicht in:	Chemistry : a European journal 2015-01, Vol.21 (1), p.n/a
Hauptverfasser:	Barandun, Luzi J., Ehrmann, Frederik R., Zimmerli, Daniel, Immekus, Florian, Giroud, Maude, Grünenfelder, Claudio, Schweizer, W. Bernd, Bernet, Bruno, Betz, Michael, Heine, Andreas, Klebe, Gerhard, Diederich, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry molecular recognition phosphate binding sites shigellosis structure-based design water cluster
Online-Zugang:	Volltext
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