Frontispiece: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT)

Molecular Recognition In their Full Paper on page 126 ff., G. Klebe, F. Diederich et al. describe a novel series of lin‐benzoguanines that target the polar ribose‐34 pocket of Z. mobilis TGT with a furanosyl moiety. The preparation involved a new cyclization strategy for the lin‐benzoguanine core and the highly challenging separation of the anomeric mixtures by HPLC on a chiral stationary phase. They were designed to replace a conserved water cluster and differ by the functional groups at C(2) and C(3) of the furanosyl moiety being either OH or OMe.