Direct Arylation of Imidazo[1,5-a]azines Through Ruthenium and Palladium Catalysis

The regioselective RuII‐catalyzed direct ortho‐arylation of C‐3 aryl‐substituted imidazo[1,5‐a]azines with (hetero)aryl halides was investigated. The employment of RuII and PdII catalysts in the same flask resulted in two sequential and distinct C–H bond arylations, which allowed the rapid synthesis of highly conjugated compounds. The RuII‐catalyzed direct ortho‐arylation of C‐3‐substituted imidazo[1,5‐a]azines with (hetero)aryl halides is investigated. Multiple arylations are performed sequentially in a one‐pot procedure with the use of RuII and PdII catalysts.