Theranostics: An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System (Small 24/2014)
A new nanoparticle system with multimodal imaging features functionalized with immunostimulatory dsRNA (poly (I:C)) is reported by J. C. Mareque‐Rivas and co‐workers. As described on page 5054, the nanocarrier is capable of reaching endosomal TLR3 in cells of the immune system, significantly enhanci...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2014-12, Vol.10 (24), p.5053-5053 |
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| creator | Cobaleda-Siles, Macarena Henriksen-Lacey, Malou de Angulo, Ane Ruiz Bernecker, Anja Vallejo, Vanessa Gómez Szczupak, Boguslaw Llop, Jordi Pastor, Géraldine Plaza-Garcia, Sandra Jauregui-Osoro, Maite Meszaros, Levente K. Mareque-Rivas, Juan C. |
| description | A new nanoparticle system with multimodal imaging features functionalized with immunostimulatory dsRNA (poly (I:C)) is reported by J. C. Mareque‐Rivas and co‐workers. As described on page 5054, the nanocarrier is capable of reaching endosomal TLR3 in cells of the immune system, significantly enhancing the capacity of poly (I:C) to trigger the induction of cytokines essential for activating the immune system. MRI and SPECT are combined to elucidate its delivery to lymph nodes – the command centres of the immune system. |
| doi_str_mv | 10.1002/smll.201470156 |
| format | Article |
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| subjects | drug delivery immunotherapy multifunctional nanoparticles multimodal imaging Nanotechnology theranostics Toll-like receptors |
| title | Theranostics: An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System (Small 24/2014) |
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