Theranostics: An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System (Small 24/2014)

Theranostics: An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System (Small 24/2014)

A new nanoparticle system with multimodal imaging features functionalized with immunostimulatory dsRNA (poly (I:C)) is reported by J. C. Mareque‐Rivas and co‐workers. As described on page 5054, the nanocarrier is capable of reaching endosomal TLR3 in cells of the immune system, significantly enhanci...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2014-12, Vol.10 (24), p.5053-5053
Hauptverfasser: Cobaleda-Siles, Macarena, Henriksen-Lacey, Malou, de Angulo, Ane Ruiz, Bernecker, Anja, Vallejo, Vanessa Gómez, Szczupak, Boguslaw, Llop, Jordi, Pastor, Géraldine, Plaza-Garcia, Sandra, Jauregui-Osoro, Maite, Meszaros, Levente K., Mareque-Rivas, Juan C.
Format: Artikel
Sprache:eng
Schlagworte:
drug delivery
immunotherapy
multifunctional nanoparticles
multimodal imaging
Nanotechnology
theranostics
Toll-like receptors
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Zusammenfassung:A new nanoparticle system with multimodal imaging features functionalized with immunostimulatory dsRNA (poly (I:C)) is reported by J. C. Mareque‐Rivas and co‐workers. As described on page 5054, the nanocarrier is capable of reaching endosomal TLR3 in cells of the immune system, significantly enhancing the capacity of poly (I:C) to trigger the induction of cytokines essential for activating the immune system. MRI and SPECT are combined to elucidate its delivery to lymph nodes – the command centres of the immune system.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201470156