A Versatile Total Synthesis of Trachycladines A and B and Their Analogues

The synthesis of marine nucleosides trachycladines A and B and two nucleoside analogues was accomplished following a versatile and high‐yielding scheme starting from D‐ribose. The key step involved a regio‐ and stereoselective direct Vorbrüggen glycosylation reaction between the appropriate nucleobase and a common intermediate, 2‐C‐methyl‐D‐5‐deoxyribofuranose triacetate. Marine nucleosides trachycladines A and B were synthesized from D‐ribose, using a versatile and high‐yielding scheme. The same approach was followed to prepare two analogues.