The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
Highlights • The retinoblastoma (Rb) protein modulates the response of human liver cancer cells to sorafenib. • Sorafenib is more cytotoxic in cells with reduced levels of Rb. • Rb knock-down cells exposed to sorafenib encounter ferroptosis, a new form of regulated necrosis. • Rb-negative cancer cel...
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| Veröffentlicht in: | Cancer letters 2015-01, Vol.356 (2), p.971-977 |
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| container_title | Cancer letters |
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| creator | Louandre, Christophe Marcq, Ingrid Bouhlal, Hicham Lachaier, Emma Godin, Corinne Saidak, Zuzana François, Catherine Chatelain, Denis Debuysscher, Véronique Barbare, Jean-Claude Chauffert, Bruno Galmiche, Antoine |
| description | Highlights • The retinoblastoma (Rb) protein modulates the response of human liver cancer cells to sorafenib. • Sorafenib is more cytotoxic in cells with reduced levels of Rb. • Rb knock-down cells exposed to sorafenib encounter ferroptosis, a new form of regulated necrosis. • Rb-negative cancer cells encounter increased levels of oxidative stress. |
| doi_str_mv | 10.1016/j.canlet.2014.11.014 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 28, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-174038d4111fbada1e1c6cfefd82257b1fb61013b6e56730ea73eaebd0ce604a3</citedby><cites>FETCH-LOGICAL-c511t-174038d4111fbada1e1c6cfefd82257b1fb61013b6e56730ea73eaebd0ce604a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383514006703$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25444922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Louandre, Christophe</creatorcontrib><creatorcontrib>Marcq, Ingrid</creatorcontrib><creatorcontrib>Bouhlal, Hicham</creatorcontrib><creatorcontrib>Lachaier, Emma</creatorcontrib><creatorcontrib>Godin, Corinne</creatorcontrib><creatorcontrib>Saidak, Zuzana</creatorcontrib><creatorcontrib>François, Catherine</creatorcontrib><creatorcontrib>Chatelain, Denis</creatorcontrib><creatorcontrib>Debuysscher, Véronique</creatorcontrib><creatorcontrib>Barbare, Jean-Claude</creatorcontrib><creatorcontrib>Chauffert, Bruno</creatorcontrib><creatorcontrib>Galmiche, Antoine</creatorcontrib><title>The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • The retinoblastoma (Rb) protein modulates the response of human liver cancer cells to sorafenib. • Sorafenib is more cytotoxic in cells with reduced levels of Rb. • Rb knock-down cells exposed to sorafenib encounter ferroptosis, a new form of regulated necrosis. • Rb-negative cancer cells encounter increased levels of oxidative stress.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biomedical research</subject><subject>Blotting, Western</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cyclin-dependent kinases</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Ferroptosis</subject><subject>Genes</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria - pathology</subject><subject>Mortality</subject><subject>Necrosis</subject><subject>Niacinamide - analogs & derivatives</subject><subject>Niacinamide - pharmacology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phenylurea Compounds - pharmacology</subject><subject>Proteins</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Retinoblastoma Protein - metabolism</subject><subject>Rodents</subject><subject>Sorafenib</subject><subject>Stress measurement</subject><subject>Studies</subject><subject>Tumor Cells, Cultured</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV2L1TAUDKK419V_IFLwRR9az0nStH0RZPELFgRdn0OSnrq59jbXJBXuvzflrgq--JKBk5k5zBzGniI0CKhe7RtnlplywwFlg9gUuMd22He87oYe7rMdCJC16EV7wR6ltAeAVnbtQ3bBWynlwPmOxZtbqiJlvwQ7m5TDwVQvPtuX1TGGTH4pf9_W2WRK1UQxhmMOyafKL-PqaKzsqUohmokWb8uwul0Pprx0NDk4mucijZUz0RX_4ryN0mP2YDJzoid3eMm-vnt7c_Whvv70_uPVm-vatYi5xk6C6EeJiJM1o0FCp9xE09hz3na2TFUpQlhFreoEkOkEGbIjOFIgjbhkz8--JcqPlVLW-7DGpazUqPgwDIWlCkueWS6GlCJN-hj9wcSTRtBb0Xqvz0XrrWiNqAsU2bM789UeaPwj-t1sIbw-E6hE_Okp6uQ8LaU0H8llPQb_vw3_GrjZL96Z-TudKP3NohPXoL9sx95ujRJAdSDELy81p5U</recordid><startdate>20150128</startdate><enddate>20150128</enddate><creator>Louandre, Christophe</creator><creator>Marcq, Ingrid</creator><creator>Bouhlal, Hicham</creator><creator>Lachaier, Emma</creator><creator>Godin, Corinne</creator><creator>Saidak, Zuzana</creator><creator>François, Catherine</creator><creator>Chatelain, Denis</creator><creator>Debuysscher, Véronique</creator><creator>Barbare, Jean-Claude</creator><creator>Chauffert, Bruno</creator><creator>Galmiche, Antoine</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20150128</creationdate><title>The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells</title><author>Louandre, Christophe ; Marcq, Ingrid ; Bouhlal, Hicham ; Lachaier, Emma ; Godin, Corinne ; Saidak, Zuzana ; François, Catherine ; Chatelain, Denis ; Debuysscher, Véronique ; Barbare, Jean-Claude ; Chauffert, Bruno ; Galmiche, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-174038d4111fbada1e1c6cfefd82257b1fb61013b6e56730ea73eaebd0ce604a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biomedical research</topic><topic>Blotting, Western</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Proliferation - drug effects</topic><topic>Cyclin-dependent kinases</topic><topic>Cytotoxicity</topic><topic>Female</topic><topic>Ferroptosis</topic><topic>Genes</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical prognosis</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondria - 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2015-01, Vol.356 (2), p.971-977 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biomedical research Blotting, Western Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation - drug effects Cyclin-dependent kinases Cytotoxicity Female Ferroptosis Genes Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma Humans Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Mice Mice, Inbred BALB C Mice, Nude Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mortality Necrosis Niacinamide - analogs & derivatives Niacinamide - pharmacology Oxidative stress Oxidative Stress - drug effects Phenylurea Compounds - pharmacology Proteins Reactive Oxygen Species - metabolism Retinoblastoma Protein - metabolism Rodents Sorafenib Stress measurement Studies Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| title | The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells |
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