The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

Highlights • The retinoblastoma (Rb) protein modulates the response of human liver cancer cells to sorafenib. • Sorafenib is more cytotoxic in cells with reduced levels of Rb. • Rb knock-down cells exposed to sorafenib encounter ferroptosis, a new form of regulated necrosis. • Rb-negative cancer cel...

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Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (2), p.971-977
Hauptverfasser:	Louandre, Christophe, Marcq, Ingrid, Bouhlal, Hicham, Lachaier, Emma, Godin, Corinne, Saidak, Zuzana, François, Catherine, Chatelain, Denis, Debuysscher, Véronique, Barbare, Jean-Claude, Chauffert, Bruno, Galmiche, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biomedical research Blotting, Western Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation - drug effects Cyclin-dependent kinases Cytotoxicity Female Ferroptosis Genes Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma Humans Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Mice Mice, Inbred BALB C Mice, Nude Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mortality Necrosis Niacinamide - analogs & derivatives Niacinamide - pharmacology Oxidative stress Oxidative Stress - drug effects Phenylurea Compounds - pharmacology Proteins Reactive Oxygen Species - metabolism Retinoblastoma Protein - metabolism Rodents Sorafenib Stress measurement Studies Tumor Cells, Cultured Xenograft Model Antitumor Assays
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Zusammenfassung:	Highlights • The retinoblastoma (Rb) protein modulates the response of human liver cancer cells to sorafenib. • Sorafenib is more cytotoxic in cells with reduced levels of Rb. • Rb knock-down cells exposed to sorafenib encounter ferroptosis, a new form of regulated necrosis. • Rb-negative cancer cells encounter increased levels of oxidative stress.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.11.014