Synthesis of N -(2-pyridyl)imidazolidin-2-ones and 1-(2-pyridyl)-2,3,7,8-tetrahydro-1 H -imidazo[2,1- b ][1,3,5]triazepin-5(6 H )-ones with potential biological activities

Small libraries of 1-(2-pyridyl)imidazolidin-2-one and 1-(2-pyridyl)-2,3,7,8-tetrahydro-1 H -imidazo[2,1- b ]- [1,3,5]triazepin-5(6 H )-one derivatives were prepared from substituted pyridine or quinoline N -oxides and 2-chloro-4,5-dihydroimidazole by means of the α-ureation and α-amination reactions. The α-ureation reaction of pyridine and quinoline N -oxides was studied theoretically by means of quantum chemical calculations at the density functional theory level. The newly obtained compounds were screened for their potential in vitro cytotoxic activity against human tumor cell lines LCLC-103H, 5637 and A-427.