Synthesis and antifungal activity of camphoric acid-based acylhydrazone compounds

In the search of novel potent bioactive compounds, 18 novel camphoric acid-based acylhydrazone compounds were designed and synthesized by the condensation reaction of -amino camphorimide ( ) with substituted benzaldehyde based on camphoric acid as the starting material. The target compounds were characterized by means of Fourier transform infrared (FTIR), H nuclear magnetic resonance (NMR), C NMR, electrospray ionization-mass spectrometry (ESI-MS), and elemental analysis. The preliminary bioassay showed that the following camphoric acid-based compounds exhibited excellent antifungal activity with an inhibition ratio of 95% against at the concentration of 50 μg ml : -bromophenyl acylhydrazone ( ), -bromophenyl acylhydrazone ( ), -methoxyphenyl acylhydrazone ( ), and -hydroxyphenyl acylhydrazone ( ).