Motif-optimized subtype A HIVenvelope-basedDNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially

Motif-optimized subtype A HIVenvelope-basedDNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially

Highlights * Immunization with naturally evolving env genes, given sequentially, is promising. * Motif-optimized env sequences were superior to wild type for neutralizing antibodies. * Simultaneous boosting with DNA and protein at different sites enhanced antibodies. * Antibodies that neutralized he...

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Veröffentlicht in:Vaccine 2012-08, Vol.30 (37), p.5519
Hauptverfasser: Pissani, Franco, Malherbe, Delphine C, Robins, Harlan, DeFilippis, Victor R, Park, Byung, Sellhorn, George, Stamatatos, Leonidas, Overbaugh, Julie, Haigwood, Nancy L
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
AIDS
Algorithms
Bioinformatics
Cloning
Deoxyribonucleic acid
DNA
Genes
Genomes
HIV
Human immunodeficiency virus
Immunization
Infections
Mammals
Proteins
Vaccines
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Beschreibung
Zusammenfassung:Highlights * Immunization with naturally evolving env genes, given sequentially, is promising. * Motif-optimized env sequences were superior to wild type for neutralizing antibodies. * Simultaneous boosting with DNA and protein at different sites enhanced antibodies. * Antibodies that neutralized heterologous HIV-1 isolates were obtained in rabbits.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.06.042