GW25-e3235 MicroRNA-16 represses myocardial hypertrophy by inhibiting CCND1, CCND2 and CCNE1 expression in cardiomyocytes

GW25-e3235 MicroRNA-16 represses myocardial hypertrophy by inhibiting CCND1, CCND2 and CCNE1 expression in cardiomyocytes

Methods A rat model of pressure-overload hypertrophy induced by abdominal aortic constriction (AAC), a mouse model of pressure-overload hypertrophy induced by thoracic aortic constriction (TAC) and a mouse model of hypertrophy by subcutaneous injection of phenylephrine (PE) were established.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2014-10, Vol.64 (16), p.C50-C50
Hauptverfasser: Zhixin, Shan, Shu-Lin, Wu
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiomyocytes
Cardiovascular
Cell cycle
Genotype & phenotype
Internal Medicine
Rodents
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Zusammenfassung:Methods A rat model of pressure-overload hypertrophy induced by abdominal aortic constriction (AAC), a mouse model of pressure-overload hypertrophy induced by thoracic aortic constriction (TAC) and a mouse model of hypertrophy by subcutaneous injection of phenylephrine (PE) were established.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.06.244