Protective immunity against tick infestation in cattle vaccinated with recombinant trypsin inhibitor ofRhipicephalus microplus

Protective immunity against tick infestation in cattle vaccinated with recombinant trypsin inhibitor ofRhipicephalus microplus

Highlights * Tested vaccine with recombinant Kunitz protein for cattle tick immunoprotection. * LarvalR.microplustrypsin inhibitor was produced in yeast expression system. * Immunization afforded 32% efficacy against cattle tick infestation. * LarvalR.microplustrypsin inhibitor resembles three-heade...

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Veröffentlicht in:Vaccine 2012-10, Vol.30 (47), p.6678
Hauptverfasser: Andreotti, Renato, Cunha, Rodrigo Casquero, Soares, Mariana Aparecida, Guerrero, Felix D, Leivas Leite, Fábio P, Pérez de León, Adalberto A
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Antigens
Arachnids
Bioinformatics
Cattle
Deoxyribonucleic acid
DNA
Experiments
Females
Immunization
Laboratories
Proteins
Software
Studies
Vaccines
Yeasts
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Beschreibung
Zusammenfassung:Highlights * Tested vaccine with recombinant Kunitz protein for cattle tick immunoprotection. * LarvalR.microplustrypsin inhibitor was produced in yeast expression system. * Immunization afforded 32% efficacy against cattle tick infestation. * LarvalR.microplustrypsin inhibitor resembles three-headed Kunitz protein BmTI-6.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.08.066