$Poor efficacy and tolerability of R‐CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation$

Poor efficacy and tolerability of R‐CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation

This phase II trial evaluated efficacy and tolerability of R‐CHOP for up to 8 courses in Richter transformation (RT) and up to 6 courses in CLL plus autoimmune cytopenia (AIC) or high‐risk (HR) features. HR was defined as fludarabine‐refractoriness or early relapse (

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of hematology 2014-12, Vol.89 (12), p.E239-E243
Hauptverfasser:	Langerbeins, Petra, Busch, Raymonde, Anheier, Nadine, Dürig, Jan, Bergmann, Manuela, Goebeler, Maria‐Elisabeth, Hurtz, Hans‐Jürgen, Stauch, Martina B., Stilgenbauer, Stephan, Döhner, Hartmut, Fink, Anna‐Maria, Cramer, Paula, Fischer, Kirsten, Wendtner, Clemens‐Martin, Hallek, Michael, Eichhorst, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Murine-Derived - administration & dosage Antibodies, Monoclonal, Murine-Derived - adverse effects Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Doxorubicin - administration & dosage Doxorubicin - adverse effects Drug Administration Schedule Drug Resistance, Neoplasm Female Hematology Hemoglobins - metabolism Humans Leukemia, Lymphocytic, Chronic, B-Cell - complications Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Middle Aged Prednisone - administration & dosage Prednisone - adverse effects Purpura, Thrombocytopenic, Idiopathic - complications Purpura, Thrombocytopenic, Idiopathic - drug therapy Purpura, Thrombocytopenic, Idiopathic - mortality Purpura, Thrombocytopenic, Idiopathic - pathology Recurrence Survival Analysis Treatment Failure Vidarabine - analogs & derivatives Vidarabine - therapeutic use Vincristine - administration & dosage Vincristine - adverse effects
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Beschreibung
Zusammenfassung:	This phase II trial evaluated efficacy and tolerability of R‐CHOP for up to 8 courses in Richter transformation (RT) and up to 6 courses in CLL plus autoimmune cytopenia (AIC) or high‐risk (HR) features. HR was defined as fludarabine‐refractoriness or early relapse (
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.23841