Investigation of various impurities in febuxostat

Investigation of various impurities in febuxostat

Hydroxybenzenecarbothioamide (impurity Vlll). Magnesium chloride hexahydrate (MgCI2.6H20, 34.1 g, 0.167 mol) was added to a stirred solution of 2-cyanophenol (10.0 g, 0.084 mol) in dimethylformamide (DMF, 100 mL) at 25 °C. To this solution, 30% sodium hydrosulfide (NaHS, 46.9 mL, 0.252 mol) was adde...

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Veröffentlicht in:Pharmaceutical technology Europe 2014-09, Vol.26 (9), p.62
Hauptverfasser: Lahoti, Anand M, Ravi, Ponnaiah, Kumar, Neela Praveen, Innareddy, V, Deepthi, P.S, Shanmugam, V, Rao, M. Sudhakar, Reddy, Vivekananda
Format: Artikel
Sprache:eng
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By products
Chemical synthesis
Chromatography
Clinical trials
Fourier transforms
Inhibitor drugs
NMR
Nuclear magnetic resonance
Patient safety
Pharmaceutical industry
Potassium
Production processes
Rheumatism
Solvents
Uric acid
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Zusammenfassung:Hydroxybenzenecarbothioamide (impurity Vlll). Magnesium chloride hexahydrate (MgCI2.6H20, 34.1 g, 0.167 mol) was added to a stirred solution of 2-cyanophenol (10.0 g, 0.084 mol) in dimethylformamide (DMF, 100 mL) at 25 °C. To this solution, 30% sodium hydrosulfide (NaHS, 46.9 mL, 0.252 mol) was added at 25 °C. The reaction mixture was heated to 45-50 °C for 15-18 h. Reaction progress was monitored by thin layer chromatography (TLC).
ISSN:1753-7967