CXCR2 inhibition protects against chronic pancreatitis in a murine model

CXCR2 inhibition protects against chronic pancreatitis in a murine model

To examine the importance of neutrophils in this process we used a neutrophil blocking antibody and found that there was significant pancreatic damage from macrophage infiltration despite neutrophil blockade. [...]CXCR2 inhibition may protect patients with early chronic pancreatitis from pancreatic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-01, Vol.13 (1), p.e5-e5
Hauptverfasser: Steele, C.W, Morton, J.P, McKay, C.J, Evans, T.R.J, Carter, C.R, Sansom, O.J
Format: Artikel
Sprache:eng
Schlagworte:
Chemokines
Endocrinology & Metabolism
Gastroenterology and Hepatology
Pancreas
Rodents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To examine the importance of neutrophils in this process we used a neutrophil blocking antibody and found that there was significant pancreatic damage from macrophage infiltration despite neutrophil blockade. [...]CXCR2 inhibition may protect patients with early chronic pancreatitis from pancreatic damage in a process dependent on both neutrophil and macrophage chemotaxis.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.016