Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressingStreptococcus pneumoniaepopulations

Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressingStreptococcus pneumoniaepopulations

Highlights * During the OPK assay pilus-expressing pneumococci are selectively killed by RrgB321 antisera. * In the OPK assay no switch towards the pilus non-expressing phenotype was observed. * Mice immunized with RrgB321 are protected against challenge with either the H or L pilus-expressing popul...

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Veröffentlicht in:Vaccine 2012-02, Vol.30 (7), p.1349
Hauptverfasser: Moschioni, Monica, De Angelis, Gabriella, Harfouche, Carole, Bizzarri, Esmeralda, Filippini, Sara, Mori, Elena, Mancuso, Giuseppe, Doro, Francesco, Barocchi, Michèle A, Ruggiero, Paolo, Masignani, Vega
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Bacteriology
Ear diseases
Immunization
Mortality
Plasmids
Protein expression
Proteins
Streptococcus infections
Studies
Vaccines
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Zusammenfassung:Highlights * During the OPK assay pilus-expressing pneumococci are selectively killed by RrgB321 antisera. * In the OPK assay no switch towards the pilus non-expressing phenotype was observed. * Mice immunized with RrgB321 are protected against challenge with either the H or L pilus-expressing populations. * Immunization with RrgB321 can be effective to protect against the disease caused by all pilus islet-1 positive isolates.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.12.080