The immune enhancement of a novel soy lecithin/[beta]-glucans based adjuvant on nativeNeospora caninumtachyzoite extract vaccine in mice

The immune enhancement of a novel soy lecithin/[beta]-glucans based adjuvant on nativeNeospora caninumtachyzoite extract vaccine in mice

Highlights * We demonstrate the immune enhancement of a tailoredN. caninumvaccine in mice. * Vaccine antigen was selected based on its capacity to activate dendritic cells. * Vaccines withProvidean-AVEC®adjuvant limitedN. caninuminfection. * A tenth of the antigen payload was needed compared to othe...

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Veröffentlicht in:Vaccine 2012-02, Vol.30 (6), p.1124
Hauptverfasser: Mansilla, Florencia Celeste, Franco-Mahecha, Olga Lucía, Lavoria, María Ángeles, Moore, Dadín Prando, Giraldez, Adrián Nicolás, Iglesias, Marcela Elvira, Wilda, Maximiliano, Capozzo, Alejandra Victoria
Format: Artikel
Sprache:eng
Schlagworte:
Medical research
Parasites
Studies
Vaccines
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Zusammenfassung:Highlights * We demonstrate the immune enhancement of a tailoredN. caninumvaccine in mice. * Vaccine antigen was selected based on its capacity to activate dendritic cells. * Vaccines withProvidean-AVEC®adjuvant limitedN. caninuminfection. * A tenth of the antigen payload was needed compared to other aqueous adjuvants. * Protective responses againstN. caninumentailed systemic IgG2a and IFN-γ.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.12.007