A New Stereoselective Total Synthesis of Phomonol

A New Stereoselective Total Synthesis of Phomonol

A stereoselective total synthesis of phomonol, following organocatalytic enantioselective epoxidation and intramolecular oxa‐Michael reaction as key steps, is described. The use of readily available D‐tartaric acid as a chiral source renders this approach quite simple and attractive.

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Bibliographische Detailangaben
Veröffentlicht in:Helvetica chimica acta 2014-10, Vol.97 (10), p.1326-1332
Hauptverfasser: Subba Reddy, Basi V., Srinivas, Lavudia, Sivaramakrishna Reddy, Pathuri, Phaneendra Reddy, Bhemavarapu, Prasad, Attaluri R., Yadav, Jhillu S.
Format: Artikel
Sprache:eng
Schlagworte:
intramolecular
MacMillan asymmetric epoxidation
Oxa-Michael reaction
Oxa‐Michael reaction, intramolecular
Pyran
Pyran, tetrahydro
tetrahydro
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Zusammenfassung:A stereoselective total synthesis of phomonol, following organocatalytic enantioselective epoxidation and intramolecular oxa‐Michael reaction as key steps, is described. The use of readily available D‐tartaric acid as a chiral source renders this approach quite simple and attractive.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201300458