The role of mitochondrial dysfunction in the pathophysiology of ICU-acquired weakness

The role of mitochondrial dysfunction in the pathophysiology of ICU-acquired weakness

Upregulation of complex II may represent an adaptive phenomenon as skeletal muscle during critical illness is more reliant on fatty oxidation (which feeds electrons to respiratory chain via complex II), because of insulin resistance and impaired oxidative glucose disposal.

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Bibliographische Detailangaben
Veröffentlicht in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2014-10, Vol.30 (10), p.1222-1222
Hauptverfasser: Jiroutkova, K, Ziak, J, Krajcova, A, Fric, M, Dzupa, V, Duska, F
Format: Artikel
Sprache:eng
Schlagworte:
Gastroenterology and Hepatology
Insulin resistance
Mitochondrial DNA
Musculoskeletal system
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Beschreibung
Zusammenfassung:Upregulation of complex II may represent an adaptive phenomenon as skeletal muscle during critical illness is more reliant on fatty oxidation (which feeds electrons to respiratory chain via complex II), because of insulin resistance and impaired oxidative glucose disposal.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2014.07.019