Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N-(Substituted-thioureido)aminobicyclo Dicarboximide and 3,4-Disubstituted 1,2,4-Triazolino-5-thione

The novel N‐(substituted‐thioureido)aminobicyclo dicarboximide and 3,4‐disubstituted 1,2,4‐triazolino‐5‐thione were synthesized and their antimicrobial and antituberculosis activities were examined. Selected dicarboxylic acid anhydrides were used to obtain derivatives of thiosemicarbazide and dicarboximide. Dicarboximides were also cyclized in the presence of an alkaline solution giving 1,2,4‐triazolino‐5‐thione. The chemical structure of all compounds was confirmed by IR, 1H NMR, 13C NMR, the X‐ray crystallography (6, 11) and elemental analysis. Antimicrobial and antituberculosis activities of the derivatives were measured. The novel N‐(substituted‐thio‐ ureido)aminobicyclo dicarbox‐ imide and 3,4‐disubstituted 1,2,4‐ triazolino‐5‐thione were synthesized and their anti‐ microbial and antituberculosis activities were examined. Selected dicarboxylic acid anhydrides were used to obtain derivatives of thiosemicarbazide and dicarbox‐ imide. Dicarboximides were also cyclized in the presence of an alkaline solution giving 1,2,4‐ triazolino‐5‐thione.