Microwave-Assisted One-Pot Synthesis of Substituted 3-Bromoimidazo[1,2-a]pyridines and Imidazoheterocycles

Microwave-Assisted One-Pot Synthesis of Substituted 3-Bromoimidazo[1,2-a]pyridines and Imidazoheterocycles

Herein, an efficient, one‐pot microwave‐assisted synthesis of a diverse set of 3‐bromoimidazo[1,2‐a]pyridines is being reported with good yields (40–85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This...

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Veröffentlicht in:Journal of heterocyclic chemistry 2014-09, Vol.51 (5), p.1509-1515
Hauptverfasser: Patil, Shashikant M., Mascarenhas, Malcolm, Sharma, Rajiv, Mohana Roopan, S., Roychowdhury, Abhijit
Format: Artikel
Sprache:eng
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Zusammenfassung:Herein, an efficient, one‐pot microwave‐assisted synthesis of a diverse set of 3‐bromoimidazo[1,2‐a]pyridines is being reported with good yields (40–85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles. Copyright © 2014 HeteroCorporation
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1764