A Facile One-Pot Synthesis of Chloropyridines from Chalcones

A Facile One-Pot Synthesis of Chloropyridines from Chalcones

Malononitrile undergoes Michael addition to iminoalkylated chalcones under Vilsmeier–Haack reaction condition. In situ intramolecular cyclization followed by aromatization of the adduct resulted in the formation of 4,6‐bis(aryl)‐2‐chloropyridines in good yields.

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Veröffentlicht in:Journal of heterocyclic chemistry 2014-09, Vol.51 (5), p.1385-1389
Hauptverfasser: Menon, Prasanth K., Krishnaraj, K. U., George, Sholly C., Devaky, K. S., Anabha, E. R.
Format: Artikel
Sprache:eng
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Zusammenfassung:Malononitrile undergoes Michael addition to iminoalkylated chalcones under Vilsmeier–Haack reaction condition. In situ intramolecular cyclization followed by aromatization of the adduct resulted in the formation of 4,6‐bis(aryl)‐2‐chloropyridines in good yields.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1790