Revisiting the Bromination of CH Bonds with Molecular Bromine by Using a Photo-Microflow System

The photobromination of CH bonds by using molecular bromine was reinvestigated under microfluidic conditions. The continuous-flow method suppressed the production of dibrominated compounds and effectively produced the desired monobrominated products with high selectivity. Rapid bromination of benzyl...

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Veröffentlicht in:	Chemistry : a European journal 2014-09, Vol.20 (40), p.12750
Hauptverfasser:	Manabe, Yoshiyuki, Kitawaki, Yuriko, Nagasaki, Masahiro, Fukase, Koichi, Matsubara, Hiroshi, Hino, Yoshiko, Fukuyama, Takahide, Ryu, Ilhyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
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Beschreibung
Zusammenfassung:	The photobromination of CH bonds by using molecular bromine was reinvestigated under microfluidic conditions. The continuous-flow method suppressed the production of dibrominated compounds and effectively produced the desired monobrominated products with high selectivity. Rapid bromination of benzylic substrates containing a photoaffinity azide group was achieved without any decomposition.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201402303