Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer

Highlights • HS-345 inhibited the TrkA/Akt pathway in pancreatic cancer cells. • HS-345 induced apoptosis of pancreatic cancer cells. • HS-345 suppressed cell growth/proliferation and angiogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2013-09, Vol.338 (2), p.271-281
Hauptverfasser:	Seo, Ju Hyeon, Jung, Kyung Hee, Son, Mi Kwon, Yan, Hong Hua, Ryu, Ye-Lim, Kim, Jinhee, Lee, Jung Kyun, Hong, Sungwoo, Hong, Soon-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals anticarcinogenic activity Apoptosis Apoptosis - drug effects blood Cancer therapies carcinogenicity caspase-3 Cell adhesion & migration Cell growth Cell Growth Processes - drug effects Cell Line, Tumor Chromatography Cytotoxicity Drug Screening Assays, Antitumor growth retardation Hematology, Oncology and Palliative Medicine HS-345 human umbilical vein endothelial cells Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Humans Male mechanism of action Medical prognosis membrane potential Metastasis Mice Mice, Inbred BALB C mitochondrial membrane Mortality Neovascularization, Pathologic - drug therapy Pancreas Pancreatic cancer pancreatic neoplasms Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Receptor Protein-Tyrosine Kinases - antagonists & inhibitors signal transduction Signal Transduction - drug effects Sulfonamides - pharmacology Tropomyosin-related kinase A (TrkA) Tumors
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Beschreibung
Zusammenfassung:	Highlights • HS-345 inhibited the TrkA/Akt pathway in pancreatic cancer cells. • HS-345 induced apoptosis of pancreatic cancer cells. • HS-345 suppressed cell growth/proliferation and angiogenesis.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.04.002