Histone methyltransferase SMYD3 promotes MRTF-A-mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells

Highlights • H3K4 methylation is involved in MRTF-A-mediated transactivation. • H3K4 methylation is implicated in MRTF-A-mediated migration of breast cancer cells. • Histone methyltransferase SMYD3 might be a coactivator for the function of MRTF-A.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-03, Vol.344 (1), p.129-137
Hauptverfasser:	Luo, Xue-Gang, Zhang, Chun-Ling, Zhao, Wen-Wen, Liu, Zhi-Peng, Liu, Lei, Mu, Ai, Guo, Shu, Wang, Nan, Zhou, Hao, Zhang, Tong-Cun
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell adhesion & migration Cell Movement DNA-Binding Proteins - metabolism Genes Hematology, Oncology and Palliative Medicine Histone-Lysine N-Methyltransferase - metabolism Humans Immunohistochemistry Immunoprecipitation MCF-7 Cells Metastasis Morphogenesis Neoplasm Invasiveness Nuclear Proteins - metabolism Oncogene Proteins, Fusion - metabolism Plasmids Promyelocytic Leukemia Protein Proteins Reverse Transcriptase Polymerase Chain Reaction RNA polymerase RNA, Small Interfering Trans-Activators Transcription Factors - metabolism Transcriptional Activation Transfection Tumor Suppressor Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • H3K4 methylation is involved in MRTF-A-mediated transactivation. • H3K4 methylation is implicated in MRTF-A-mediated migration of breast cancer cells. • Histone methyltransferase SMYD3 might be a coactivator for the function of MRTF-A.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.10.026