Polistesspecies venom is devoid of carbohydrate-based cross-reactivity and allows interference-free diagnostics

[...]it represents a much better diagnostic tool than previously anticipated.1 Although facilitated by the lack of CCD-based interference in PV, the discrimination of PV and YJV allergy still remains difficult, and often requires additional laboratory tests (eg, IgE inhibition assays) to distinguish primary sensitization and protein-based cross-reactivity.1 These tests are expensive, time consuming, difficult to interpret, and thus rarely used in clinical routine.