TAT-HKIIInduced Reduction in Mitochondrial Bound Hexokinase II Increases Ischemia Reperfusion Injury by Increased Respiration and Increased Ros Levels

TAT-HKIIInduced Reduction in Mitochondrial Bound Hexokinase II Increases Ischemia Reperfusion Injury by Increased Respiration and Increased Ros Levels

During reperfusion, necrosis was measured by lactate dehydrogenase (LDH) activity in effluent.In the 1 [micro]M TAT-HKII hearts, MV-O/RPP was increased and mitochondrial oxygen tension was reduced during peptide treatment.

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Veröffentlicht in:Clinical therapeutics 2014-08, Vol.36 (8), p.e13
Hauptverfasser: Nederlof, R, Gürel, E, Xie, C, Eerbeek, O, Koeman, A, Hollmann, MW, Southworth, R, Akar, FG, Mik, EG, Zuurbier, CJ
Format: Artikel
Sprache:eng
Schlagworte:
Ischemia
Oxygen
Rodents
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Zusammenfassung:During reperfusion, necrosis was measured by lactate dehydrogenase (LDH) activity in effluent.In the 1 [micro]M TAT-HKII hearts, MV-O/RPP was increased and mitochondrial oxygen tension was reduced during peptide treatment.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2014.05.051