Versatile CuI/Pd0 Dual Catalysis for the Synthesis of Quaternary [alpha]-Allylated Carbonyl Compounds: Development, Mechanistic Investigations and Scope

We report herein a versatile cooperative dual catalysis reaction based on a CuI/Pd0 system. Mechanistic investigation shows that every component plays a crucial role in determining the reaction outcome. The reaction is successfully extended to various substrates; such as [alpha],[beta]-unsaturated ketones, malonates and coumarins. The strategy tolerates different substitution patterns and affords good yields for each family of substrates.