Contribution of "en face" SD‐OCT in retinal toxicity

PURPOSE: To assess retinal and choroidal changes in drug‐induced retinal toxicity using "en‐face" and BScan OCT images. METHODS: All patients underwent complete ophthalmologic examination, including fundus examination and autofluorescence, color photography, fluorescein and indocyanin green angiography. Type, amount and time of drug intake was precisely assessed. RESULTS: 8 patients were analysed and included retrospectively. Retinal toxicity was induced by tamoxifen in 2 cases, by synthetic antimalarial (SAM) drug in 3 cases and by inhaled amyl nitrite ("poppers") in 3 cases. The angiographic features, B‐Scan and "en‐face" OCT scans findings were correlated. In all cases, "en‐face" OCT provided precise anatomic location of the retinal layers involved, the extend of retinal damage, as well as follow‐up of these changes. CONCLUSION: "En‐face" OCT allows full imaging and better understanding of retinal toxicity induced by tamoxifen, SAM drugs and amyl nitrite.