IGF1R tyrosine kinase inhibitor enhances the cytotoxic effect of methyl jasmonate in endometrial cancer

Highlights • Methyl jasmonate (MJ) has significant pro-apoptotic and anti-proliferative effects on endometrial cancer cells. • MJ inhibits the IGF1-induced IGF1R phosphorylation. • Inhibition of cell proliferation by MJ and IGF1R inhibitor involves PCNA and cyclin D1 downregulation. • Combination of...

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Veröffentlicht in:	Cancer letters 2014-10, Vol.352 (2), p.214-219
Hauptverfasser:	Bruchim, Ilan, Sarfstein, Rive, Reiss, Ari, Flescher, Eliezer, Werner, Haim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Apoptosis - drug effects Breast cancer Cancer therapies Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cyclopentanes - pharmacology Cytotoxicity Dose-Response Relationship, Drug Endometrial cancer Endometrial carcinoma Endometrial Neoplasms - enzymology Endometrial Neoplasms - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Female Hematology, Oncology and Palliative Medicine Humans IGF1 receptor (IGF1R) Insulin-like growth factor-1 (IGF1) Kinases Medical prognosis Methyl jasmonate NVP-AEW541 Oxylipins - pharmacology Phosphorylation Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-akt - metabolism Pyrimidines - pharmacology Pyrroles - pharmacology Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - metabolism Studies Time Factors Tumors Uterine serous carcinoma Women
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Zusammenfassung:	Highlights • Methyl jasmonate (MJ) has significant pro-apoptotic and anti-proliferative effects on endometrial cancer cells. • MJ inhibits the IGF1-induced IGF1R phosphorylation. • Inhibition of cell proliferation by MJ and IGF1R inhibitor involves PCNA and cyclin D1 downregulation. • Combination of MJ with IGF1R inhibitor has largely increased toxicity.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.06.013