MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3

Highlights • Low level expression of let-7c is associated with metastasis of NSCLC. • Let-7c suppresses cell migration and invasion in vitro. • Let-7c targets ITGB3 and MAP4K3 and regulates their expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-01, Vol.342 (1), p.43-51
Hauptverfasser:	Zhao, Bingtian, Han, Haibo, Chen, Jinfeng, Zhang, Zhiqian, Li, Shaolei, Fang, Fang, Zheng, Qingfeng, Ma, Yuanyuan, Zhang, Jianzhi, Wu, Nan, Yang, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Base Sequence Binding Sites Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Cell growth Cell Line, Tumor Cell Movement Disease-Free Survival Female Gene Expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Integrin beta3 - genetics Integrin beta3 - metabolism Kaplan-Meier Estimate Let-7c Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical prognosis Metastasis MicroRNA MicroRNAs - genetics Middle Aged Migration and invasion Neoplasm Invasiveness NSCLC Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism R&D Research & development RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism Rodents
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Beschreibung
Zusammenfassung:	Highlights • Low level expression of let-7c is associated with metastasis of NSCLC. • Let-7c suppresses cell migration and invasion in vitro. • Let-7c targets ITGB3 and MAP4K3 and regulates their expression.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.08.030