Enhancement of T cell-mediated immune responses to whole inactivated influenza virus by chloroquine treatmentin vivo

Enhancement of T cell-mediated immune responses to whole inactivated influenza virus by chloroquine treatmentin vivo

Highlights * Chloroquine improves cross-presentation of nonreplicating influenza virusin vitro.* Immunization combined with chloroquine improves primary and memory T cells. * Chloroquine reduces viral load following pulmonary challenge of mice with PR8 virus.

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Bibliographische Detailangaben
Veröffentlicht in:Vaccine 2013-03, Vol.31 (13), p.1717
Hauptverfasser: Garulli, Bruno, Di Mario, Giuseppina, Sciaraffia, Ester, Accapezzato, Daniele, Barnaba, Vincenzo, Castrucci, Maria R
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cytokines
Drug dosages
Experiments
Immune system
Immunization
Infections
Influenza
Lymphocytes
Peptides
Spleen
Studies
T cell receptors
Vaccines
Viral infections
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Beschreibung
Zusammenfassung:Highlights * Chloroquine improves cross-presentation of nonreplicating influenza virusin vitro.* Immunization combined with chloroquine improves primary and memory T cells. * Chloroquine reduces viral load following pulmonary challenge of mice with PR8 virus.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.01.037