Identification of a new protective antigen ofBordetella pertussis

Highlights * Iron starvation induced antigenic proteins as components of new pertussis vaccines. * IRP1-3 (BP1152) is a surface exposed iron-repressed antigen protective against infection. * The mechanism of IRP1-3-mediated immunity involves humoral and cellular response. IRP1-3 is conserved and exp...

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Veröffentlicht in:	Vaccine 2011-11, Vol.29 (47), p.8731
Hauptverfasser:	Alvarez Hayes, Jimena, Erben, Esteban, Lamberti, Yanina, Ayala, Miguel, Maschi, Fabricio, Carbone, Cecilia, Gatti, Blanca, Parisi, Gustavo, Rodriguez, Maria Eugenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Genomes Infections Mortality Proteins Teenagers Vaccines Whooping cough
Online-Zugang:	Volltext
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Zusammenfassung:	Highlights * Iron starvation induced antigenic proteins as components of new pertussis vaccines. * IRP1-3 (BP1152) is a surface exposed iron-repressed antigen protective against infection. * The mechanism of IRP1-3-mediated immunity involves humoral and cellular response. IRP1-3 is conserved and expressed in clinical isolates ofBordetella pertussis.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.07.143