Mast Cell Restricted, Tetramer-forming Tryptases Hinder Thrombin-Induced Coagulation of Plasma by Proteolytically Destroying Fibrinogen

Mast Cell Restricted, Tetramer-forming Tryptases Hinder Thrombin-Induced Coagulation of Plasma by Proteolytically Destroying Fibrinogen

Sodium citrate-treated human plasma also was incubated at 37oC for 60 min in the absence or presence of hTryptase-beta (6.6 μg) or heparin (100 μg), and the times required for thrombin to clot the samples were determined.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2011-02, Vol.127 (2), p.AB131-AB131
Hauptverfasser: Prieto-García, A, Castells, M, Wang, S, Stevens, R.L
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Coagulation
Plasma
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Zusammenfassung:Sodium citrate-treated human plasma also was incubated at 37oC for 60 min in the absence or presence of hTryptase-beta (6.6 μg) or heparin (100 μg), and the times required for thrombin to clot the samples were determined.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.522