Activated Mast Cells Instruct Bone Marrow to Produce Effector Cells of Allergic Response

Activated Mast Cells Instruct Bone Marrow to Produce Effector Cells of Allergic Response

Taken together, this study should provide a model to investigate how "the allergic nose speaks to bone marrow": 1) IgE-activated MCs release soluble factors triggering BM-Str cells to produce TSLP and other growth factors; 2) MCs-activated BM-Str cells promote the proliferation of CD34+ ce...

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Veröffentlicht in:Journal of allergy and clinical immunology 2011-02, Vol.127 (2), p.AB130-AB130
Hauptverfasser: Allakhverdi, Z, Comeau, M.R, Delespesse, G
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
Bone marrow
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Beschreibung
Zusammenfassung:Taken together, this study should provide a model to investigate how "the allergic nose speaks to bone marrow": 1) IgE-activated MCs release soluble factors triggering BM-Str cells to produce TSLP and other growth factors; 2) MCs-activated BM-Str cells promote the proliferation of CD34+ cells, their expression of TSLP-R and their differentiation into effector cells of allergic response.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.520