Enhanced antitumor effects by combination gene therapy usingMDR1gene shRNA and HSV1-tkin a xenograft mouse model
The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for theMDR1gene (shMDR) was proposed previously. We investigated the antitumor effects in anin vivomouse model of colon cancer and assessed treatment response by serial non-invasive imaging. shMD...
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| Veröffentlicht in: | Cancer letters 2010-05, Vol.291 (1), p.83 |
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| container_title | Cancer letters |
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| creator | Lee, Sang-Woo Lee, You La Lee, Yong Jin Park, Seung-Yoon Kim, In-San Choi, Tae Hyun Ha, Jeoung-Hee Ahn, Byeong-Cheol Lee, Jaetae |
| description | The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for theMDR1gene (shMDR) was proposed previously. We investigated the antitumor effects in anin vivomouse model of colon cancer and assessed treatment response by serial non-invasive imaging. shMDR-TK expressing (MTKG) tumors for the dual therapy group mice with ganciclovir and doxorubicin showed a decrease in size, while tumors in the single therapy group mice showed a moderate increase (p |
| doi_str_mv | 10.1016/j.canlet.2009.10.002 |
| format | Article |
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| ispartof | Cancer letters, 2010-05, Vol.291 (1), p.83 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_journals_1550186012 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Cameras Cancer therapies Colorectal cancer Experiments Gene expression Gene therapy Kinases Medical research Proteins Reporters Technological change Tumors |
| title | Enhanced antitumor effects by combination gene therapy usingMDR1gene shRNA and HSV1-tkin a xenograft mouse model |
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