Enhanced antitumor effects by combination gene therapy usingMDR1gene shRNA and HSV1-tkin a xenograft mouse model

Enhanced antitumor effects by combination gene therapy usingMDR1gene shRNA and HSV1-tkin a xenograft mouse model

The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for theMDR1gene (shMDR) was proposed previously. We investigated the antitumor effects in anin vivomouse model of colon cancer and assessed treatment response by serial non-invasive imaging. shMD...

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Veröffentlicht in:Cancer letters 2010-05, Vol.291 (1), p.83
Hauptverfasser: Lee, Sang-Woo, Lee, You La, Lee, Yong Jin, Park, Seung-Yoon, Kim, In-San, Choi, Tae Hyun, Ha, Jeoung-Hee, Ahn, Byeong-Cheol, Lee, Jaetae
Format: Artikel
Sprache:eng
Schlagworte:
Cameras
Cancer therapies
Colorectal cancer
Experiments
Gene expression
Gene therapy
Kinases
Medical research
Proteins
Reporters
Technological change
Tumors
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Zusammenfassung:The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for theMDR1gene (shMDR) was proposed previously. We investigated the antitumor effects in anin vivomouse model of colon cancer and assessed treatment response by serial non-invasive imaging. shMDR-TK expressing (MTKG) tumors for the dual therapy group mice with ganciclovir and doxorubicin showed a decrease in size, while tumors in the single therapy group mice showed a moderate increase (p
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2009.10.002