Safety and efficacy of levofloxacin versus rifampicin in tuberculous meningitis: an open-label randomized controlled trial

We report the efficacy and safety of levofloxacin versus rifampicin in tuberculous meningitis (TBM). In this open-label, randomized controlled trial from India, patients with TBM diagnosed on the basis of clinical, MRI and CSF findings were included. Patients with hepatic or renal dysfunction, organ...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2014-08, Vol.69 (8), p.2246-2251
Hauptverfasser:	Kalita, J, Misra, U K, Prasad, S, Bhoi, S K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antitubercular Agents - therapeutic use Aspirin - therapeutic use Clinical outcomes Cortisone Drug Therapy, Combination Ethambutol - therapeutic use Female Humans Isoniazid - therapeutic use Levofloxacin - adverse effects Levofloxacin - therapeutic use Male Medical prognosis Meningitis Middle Aged NMR Nuclear magnetic resonance Prednisolone - therapeutic use Pyrazinamide - therapeutic use Radiography Rifampin - adverse effects Rifampin - therapeutic use Treatment Outcome Tuberculosis, Meningeal - diagnostic imaging Tuberculosis, Meningeal - drug therapy Tuberculosis, Meningeal - mortality Young Adult
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Zusammenfassung:	We report the efficacy and safety of levofloxacin versus rifampicin in tuberculous meningitis (TBM). In this open-label, randomized controlled trial from India, patients with TBM diagnosed on the basis of clinical, MRI and CSF findings were included. Patients with hepatic or renal dysfunction, organ transplantation, malignancy, pregnancy, lactation, allergy, seizure, age
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dku103