CHORDAL RUPTURE CORRELATES WITH ELASTIC FIBRIL FRAGMENTATION AND DISORGANIZATION OF THE POSTERIOR LEAFLET IN MYXOMATOUS MITRAL VALVE PROLAPSE: IMPLICATIONS FOR LEAFLET STABILITY AND DISEASE PROGRESSION

CHORDAL RUPTURE CORRELATES WITH ELASTIC FIBRIL FRAGMENTATION AND DISORGANIZATION OF THE POSTERIOR LEAFLET IN MYXOMATOUS MITRAL VALVE PROLAPSE: IMPLICATIONS FOR LEAFLET STABILITY AND DISEASE PROGRESSION

In myxomatous mitral valve prolapse (MMVP), decreased type I collagen and increased type III collagen and proteoglycan deposition as a result of reduced lysyl oxidase (LOX) expression may alter elastic fibrillar organization and tensile strength of valve cusps, predisposing to chordal rupture.

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Veröffentlicht in:Journal of the American College of Cardiology 2012-03, Vol.59 (13), p.E1981-E1981
Hauptverfasser: K-Raman, Purushothaman, Purushothaman, Meerarani, Adams, David, Milla, Federico, Lento, Patrick A, O'Connor, William N, Sharma, Samin, Fuster, Valentin, Moreno, Pedro
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular
Collagen
Internal Medicine
Wound healing
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Zusammenfassung:In myxomatous mitral valve prolapse (MMVP), decreased type I collagen and increased type III collagen and proteoglycan deposition as a result of reduced lysyl oxidase (LOX) expression may alter elastic fibrillar organization and tensile strength of valve cusps, predisposing to chordal rupture.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(12)61982-2