Gene expression signature ofTP53but not its mutation status predicts response to sequential paclitaxel and 5-FU/epirubicin/cyclophosphamide in human breast cancer

Gene expression signature ofTP53but not its mutation status predicts response to sequential paclitaxel and 5-FU/epirubicin/cyclophosphamide in human breast cancer

Highlights * Correlation ofTP53mutation or p53 expression with chemosensitivity was studied in breast cancer. * Correlation ofTP53gene expression signature (GES) with chemosensitivity was also studied.* TP53GES, but notTP53mutation and p53 expression, was predictive of chemosensitivity.

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Bibliographische Detailangaben
Veröffentlicht in:Cancer letters 2011-08, Vol.307 (2), p.149
Hauptverfasser: Oshima, Kazuteru, Naoi, Yasuto, Kishi, Kazuki, Nakamura, Yukiko, Iwamoto, Takashi, Shimazu, Kenzo, Nakayama, Takahiro, Kim, Seung Jin, Baba, Yosuke, Tamaki, Yasuhiro, Noguchi, Shinzaburo
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Breast cancer
Chemotherapy
Deoxyribonucleic acid
DNA
DNA repair
Gene expression
Mutation
Patients
Tumors
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Zusammenfassung:Highlights * Correlation ofTP53mutation or p53 expression with chemosensitivity was studied in breast cancer. * Correlation ofTP53gene expression signature (GES) with chemosensitivity was also studied.* TP53GES, but notTP53mutation and p53 expression, was predictive of chemosensitivity.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.03.027