Toxoplasma gondiiimmune mapped protein-1 (TgIMP1) is a novel vaccine candidate against toxoplasmosis

Toxoplasma gondiiimmune mapped protein-1 (TgIMP1) is a novel vaccine candidate against toxoplasmosis

Highlights * A DNA vaccine pcDNA-IMP1 expressingToxoplasma gondiiIMP1 was constructed. * pcDNA-IMP1 enhanced theT. gondii-specific humoral and cellular Th1 immune responses. * Mice immunized with this DNA vaccine showed significantly increased survival time. *T. gondiiIMP1 is a promising vaccine can...

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Veröffentlicht in:Vaccine 2012-03, Vol.30 (13), p.2282
Hauptverfasser: Cui, Xia, Lei, Tao, Yang, Daoyu, Hao, Pan, Li, Bo, Liu, Qun
Format: Artikel
Sprache:eng
Schlagworte:
Chemotherapy
Cytokines
Deoxyribonucleic acid
DNA
E coli
Immune system
Immunization
Infections
Laboratory animals
Parasites
Proteins
Protozoa
Toxoplasmosis
Vaccines
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Beschreibung
Zusammenfassung:Highlights * A DNA vaccine pcDNA-IMP1 expressingToxoplasma gondiiIMP1 was constructed. * pcDNA-IMP1 enhanced theT. gondii-specific humoral and cellular Th1 immune responses. * Mice immunized with this DNA vaccine showed significantly increased survival time. *T. gondiiIMP1 is a promising vaccine candidate against animal toxoplasmosis.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.01.073