Childhood asthma and early life exposure to indoor allergens, endotoxin and [beta](1,3)-glucans

Summary Background Divergent results have been reported regarding early life exposure to indoor environmental agents and the risk of asthma and allergic sensitization later in life. Objective To assess whether early exposure to indoor allergens, [beta](1,3)-glucans and endotoxin modifies the risk of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical and experimental allergy 2010-02, Vol.40 (2), p.307
Hauptverfasser: Bertelsen, R J, Lodrup Carlsen, K C, Carlsen, K-H, Granum, B, Doekes, G, Haland, G, Mowinckel, P, Lovik, M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 2
container_start_page 307
container_title Clinical and experimental allergy
container_volume 40
creator Bertelsen, R J
Lodrup Carlsen, K C
Carlsen, K-H
Granum, B
Doekes, G
Haland, G
Mowinckel, P
Lovik, M
description Summary Background Divergent results have been reported regarding early life exposure to indoor environmental agents and the risk of asthma and allergic sensitization later in life. Objective To assess whether early exposure to indoor allergens, [beta](1,3)-glucans and endotoxin modifies the risk of allergic diseases at 10 years of age. Methods The concentrations of mite, cat and dog allergens, endotoxin and [beta](1,3)-glucans were determined in dust from the homes of 260 two-year-old children with lung function measured at birth (tidal flow volume loops) in the Environment and Childhood Asthma study in Oslo. At 10 years, the health status was assessed in a follow-up study including a structured interview of the parents and an extended clinical examination. Results Cat and dog keeping at 2 years of age was reported in 6.5% and 5.5% of the families, respectively. Mite allergens were detected in only 4/260 dust samples. The adjusted odds ratio for asthma at age 10 was 1.20 (95% confidence interval: 1.01-1.43) and 1.22 (1.02-1.46) for bronchial hyperresponsiveness (BHR) per 10 µg/g dust increase in cat allergen exposure at 2 years of age. No association was seen with allergic sensitization. Moreover, endotoxin and [beta](1,3)-glucan exposure did not modify the risk of asthma or allergic sensitization. None of the measured environmental factors were associated with lung function at 10 years of age or a relative change in lung function from birth. Conclusion In a community with a low prevalence of pet keeping and low mite allergen levels, exposure to cat allergens early in life increased the risk of late childhood asthma and BHR, but not the risk of allergic sensitization. No risk modification was seen for dog allergens, endotoxin and [beta](1,3)-glucans. Cite this as: R. J. Bertelsen, K. C. Lødrup CarlsenK.-H. Carlsen, B. Granum, G. Doekes, G. Håland, P. Mowinckel and M. Løvik, Clinical & Experimental Allergy, 2010 (40) 307- 316. [PUBLICATION ABSTRACT]
doi_str_mv 10.1111/j.1365-2222.2009.03424.x
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1545770988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3376340821</sourcerecordid><originalsourceid>FETCH-proquest_journals_15457709883</originalsourceid><addsrcrecordid>eNqNi81KxDAUhcMwwtSfd7jgRmEakyaxzXpQ5gHciZRo70xbYu6YpFDf3iLier7NgfOdwxhIweXCw8ilejRltcArISwXSleazytW_Is1K4Q1uqwbqzfsMqVRCKGMbQrW7vrBdz1RBy7l_tOBCx2gi_4b_HBAwPlEaYoImWAIHVEE5z3GI4a0BVyaTPMQfm-v75jd253cqvvy6KcPF9I1uzg4n_DmL6_Y7fPTy25fniJ9TZhyO9IUw6JaabSpa2GbRp23-gHsG0vu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545770988</pqid></control><display><type>article</type><title>Childhood asthma and early life exposure to indoor allergens, endotoxin and [beta](1,3)-glucans</title><source>Access via Wiley Online Library</source><creator>Bertelsen, R J ; Lodrup Carlsen, K C ; Carlsen, K-H ; Granum, B ; Doekes, G ; Haland, G ; Mowinckel, P ; Lovik, M</creator><creatorcontrib>Bertelsen, R J ; Lodrup Carlsen, K C ; Carlsen, K-H ; Granum, B ; Doekes, G ; Haland, G ; Mowinckel, P ; Lovik, M</creatorcontrib><description>Summary Background Divergent results have been reported regarding early life exposure to indoor environmental agents and the risk of asthma and allergic sensitization later in life. Objective To assess whether early exposure to indoor allergens, [beta](1,3)-glucans and endotoxin modifies the risk of allergic diseases at 10 years of age. Methods The concentrations of mite, cat and dog allergens, endotoxin and [beta](1,3)-glucans were determined in dust from the homes of 260 two-year-old children with lung function measured at birth (tidal flow volume loops) in the Environment and Childhood Asthma study in Oslo. At 10 years, the health status was assessed in a follow-up study including a structured interview of the parents and an extended clinical examination. Results Cat and dog keeping at 2 years of age was reported in 6.5% and 5.5% of the families, respectively. Mite allergens were detected in only 4/260 dust samples. The adjusted odds ratio for asthma at age 10 was 1.20 (95% confidence interval: 1.01-1.43) and 1.22 (1.02-1.46) for bronchial hyperresponsiveness (BHR) per 10 µg/g dust increase in cat allergen exposure at 2 years of age. No association was seen with allergic sensitization. Moreover, endotoxin and [beta](1,3)-glucan exposure did not modify the risk of asthma or allergic sensitization. None of the measured environmental factors were associated with lung function at 10 years of age or a relative change in lung function from birth. Conclusion In a community with a low prevalence of pet keeping and low mite allergen levels, exposure to cat allergens early in life increased the risk of late childhood asthma and BHR, but not the risk of allergic sensitization. No risk modification was seen for dog allergens, endotoxin and [beta](1,3)-glucans. Cite this as: R. J. Bertelsen, K. C. Lødrup CarlsenK.-H. Carlsen, B. Granum, G. Doekes, G. Håland, P. Mowinckel and M. Løvik, Clinical &amp; Experimental Allergy, 2010 (40) 307- 316. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2009.03424.x</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><ispartof>Clinical and experimental allergy, 2010-02, Vol.40 (2), p.307</ispartof><rights>2009 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Bertelsen, R J</creatorcontrib><creatorcontrib>Lodrup Carlsen, K C</creatorcontrib><creatorcontrib>Carlsen, K-H</creatorcontrib><creatorcontrib>Granum, B</creatorcontrib><creatorcontrib>Doekes, G</creatorcontrib><creatorcontrib>Haland, G</creatorcontrib><creatorcontrib>Mowinckel, P</creatorcontrib><creatorcontrib>Lovik, M</creatorcontrib><title>Childhood asthma and early life exposure to indoor allergens, endotoxin and [beta](1,3)-glucans</title><title>Clinical and experimental allergy</title><description>Summary Background Divergent results have been reported regarding early life exposure to indoor environmental agents and the risk of asthma and allergic sensitization later in life. Objective To assess whether early exposure to indoor allergens, [beta](1,3)-glucans and endotoxin modifies the risk of allergic diseases at 10 years of age. Methods The concentrations of mite, cat and dog allergens, endotoxin and [beta](1,3)-glucans were determined in dust from the homes of 260 two-year-old children with lung function measured at birth (tidal flow volume loops) in the Environment and Childhood Asthma study in Oslo. At 10 years, the health status was assessed in a follow-up study including a structured interview of the parents and an extended clinical examination. Results Cat and dog keeping at 2 years of age was reported in 6.5% and 5.5% of the families, respectively. Mite allergens were detected in only 4/260 dust samples. The adjusted odds ratio for asthma at age 10 was 1.20 (95% confidence interval: 1.01-1.43) and 1.22 (1.02-1.46) for bronchial hyperresponsiveness (BHR) per 10 µg/g dust increase in cat allergen exposure at 2 years of age. No association was seen with allergic sensitization. Moreover, endotoxin and [beta](1,3)-glucan exposure did not modify the risk of asthma or allergic sensitization. None of the measured environmental factors were associated with lung function at 10 years of age or a relative change in lung function from birth. Conclusion In a community with a low prevalence of pet keeping and low mite allergen levels, exposure to cat allergens early in life increased the risk of late childhood asthma and BHR, but not the risk of allergic sensitization. No risk modification was seen for dog allergens, endotoxin and [beta](1,3)-glucans. Cite this as: R. J. Bertelsen, K. C. Lødrup CarlsenK.-H. Carlsen, B. Granum, G. Doekes, G. Håland, P. Mowinckel and M. Løvik, Clinical &amp; Experimental Allergy, 2010 (40) 307- 316. [PUBLICATION ABSTRACT]</description><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNi81KxDAUhcMwwtSfd7jgRmEakyaxzXpQ5gHciZRo70xbYu6YpFDf3iLier7NgfOdwxhIweXCw8ilejRltcArISwXSleazytW_Is1K4Q1uqwbqzfsMqVRCKGMbQrW7vrBdz1RBy7l_tOBCx2gi_4b_HBAwPlEaYoImWAIHVEE5z3GI4a0BVyaTPMQfm-v75jd253cqvvy6KcPF9I1uzg4n_DmL6_Y7fPTy25fniJ9TZhyO9IUw6JaabSpa2GbRp23-gHsG0vu</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Bertelsen, R J</creator><creator>Lodrup Carlsen, K C</creator><creator>Carlsen, K-H</creator><creator>Granum, B</creator><creator>Doekes, G</creator><creator>Haland, G</creator><creator>Mowinckel, P</creator><creator>Lovik, M</creator><general>Wiley Subscription Services, Inc</general><scope>7T5</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20100201</creationdate><title>Childhood asthma and early life exposure to indoor allergens, endotoxin and [beta](1,3)-glucans</title><author>Bertelsen, R J ; Lodrup Carlsen, K C ; Carlsen, K-H ; Granum, B ; Doekes, G ; Haland, G ; Mowinckel, P ; Lovik, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_15457709883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertelsen, R J</creatorcontrib><creatorcontrib>Lodrup Carlsen, K C</creatorcontrib><creatorcontrib>Carlsen, K-H</creatorcontrib><creatorcontrib>Granum, B</creatorcontrib><creatorcontrib>Doekes, G</creatorcontrib><creatorcontrib>Haland, G</creatorcontrib><creatorcontrib>Mowinckel, P</creatorcontrib><creatorcontrib>Lovik, M</creatorcontrib><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertelsen, R J</au><au>Lodrup Carlsen, K C</au><au>Carlsen, K-H</au><au>Granum, B</au><au>Doekes, G</au><au>Haland, G</au><au>Mowinckel, P</au><au>Lovik, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood asthma and early life exposure to indoor allergens, endotoxin and [beta](1,3)-glucans</atitle><jtitle>Clinical and experimental allergy</jtitle><date>2010-02-01</date><risdate>2010</risdate><volume>40</volume><issue>2</issue><spage>307</spage><pages>307-</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary Background Divergent results have been reported regarding early life exposure to indoor environmental agents and the risk of asthma and allergic sensitization later in life. Objective To assess whether early exposure to indoor allergens, [beta](1,3)-glucans and endotoxin modifies the risk of allergic diseases at 10 years of age. Methods The concentrations of mite, cat and dog allergens, endotoxin and [beta](1,3)-glucans were determined in dust from the homes of 260 two-year-old children with lung function measured at birth (tidal flow volume loops) in the Environment and Childhood Asthma study in Oslo. At 10 years, the health status was assessed in a follow-up study including a structured interview of the parents and an extended clinical examination. Results Cat and dog keeping at 2 years of age was reported in 6.5% and 5.5% of the families, respectively. Mite allergens were detected in only 4/260 dust samples. The adjusted odds ratio for asthma at age 10 was 1.20 (95% confidence interval: 1.01-1.43) and 1.22 (1.02-1.46) for bronchial hyperresponsiveness (BHR) per 10 µg/g dust increase in cat allergen exposure at 2 years of age. No association was seen with allergic sensitization. Moreover, endotoxin and [beta](1,3)-glucan exposure did not modify the risk of asthma or allergic sensitization. None of the measured environmental factors were associated with lung function at 10 years of age or a relative change in lung function from birth. Conclusion In a community with a low prevalence of pet keeping and low mite allergen levels, exposure to cat allergens early in life increased the risk of late childhood asthma and BHR, but not the risk of allergic sensitization. No risk modification was seen for dog allergens, endotoxin and [beta](1,3)-glucans. Cite this as: R. J. Bertelsen, K. C. Lødrup CarlsenK.-H. Carlsen, B. Granum, G. Doekes, G. Håland, P. Mowinckel and M. Løvik, Clinical &amp; Experimental Allergy, 2010 (40) 307- 316. [PUBLICATION ABSTRACT]</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/j.1365-2222.2009.03424.x</doi></addata></record>
fulltext fulltext
identifier ISSN: 0954-7894
ispartof Clinical and experimental allergy, 2010-02, Vol.40 (2), p.307
issn 0954-7894
1365-2222
language eng
recordid cdi_proquest_journals_1545770988
source Access via Wiley Online Library
title Childhood asthma and early life exposure to indoor allergens, endotoxin and [beta](1,3)-glucans
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T21%3A49%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Childhood%20asthma%20and%20early%20life%20exposure%20to%20indoor%20allergens,%20endotoxin%20and%20%5Bbeta%5D(1,3)-glucans&rft.jtitle=Clinical%20and%20experimental%20allergy&rft.au=Bertelsen,%20R%20J&rft.date=2010-02-01&rft.volume=40&rft.issue=2&rft.spage=307&rft.pages=307-&rft.issn=0954-7894&rft.eissn=1365-2222&rft_id=info:doi/10.1111/j.1365-2222.2009.03424.x&rft_dat=%3Cproquest%3E3376340821%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1545770988&rft_id=info:pmid/&rfr_iscdi=true