Palladium(II)-Catalyzed Synthesis of the Formylcarbazole Alkaloids Murrayaline A-C, 7-Methoxymukonal, and 7-Methoxy-O-methylmukonal

We describe the synthesis of the naturally occurring 2,7‐dioxygenated formylcarbazole alkaloids 7‐methoxymukonal, 7‐methoxy‐O‐methylmukonal, and the murrayalines A–C. The carbazole framework was constructed by a Buchwald–Hartwig amination and a subsequent palladium(II)‐catalyzed oxidative cyclization. We describe the synthesis of the naturally occurring 2,7‐dioxygenated formylcarbazole alkaloids 7‐methoxymukonal, 7‐methoxy‐O‐methylmukonal, and the murrayalines A–C. The carbazole framework was constructed by a Buchwald–Hartwig amination and a subsequent palladium(II)‐catalyzed oxidative cyclization.