Synthesis of Flavones and [gamma]-Benzopyranones Using Mild Sonogashira Coupling and 18-Crown-6 Ether Mediated 6-endo Cyclization
An efficient method for the synthesis of flavones and [gamma]-benzopyranones has been developed utilizing a mild Sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization of o-alkynoylphenyl acetates. By using this strategy, flavones and [gamma]-benzopyranones bearing electron-donating g...
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Veröffentlicht in: | European journal of organic chemistry 2012-08, Vol.2012 (24), p.4533 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | An efficient method for the synthesis of flavones and [gamma]-benzopyranones has been developed utilizing a mild Sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization of o-alkynoylphenyl acetates. By using this strategy, flavones and [gamma]-benzopyranones bearing electron-donating groups, halogens, and simple alkyl substituents were synthesized in satisfactory yields. [PUBLICATION ABSTRACT] |
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ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.201200529 |