The Effect of Soybean Trypsin Inhibitor on the Generation of Oxygen Free Radical in Pancreas of Mice during Different Growth Periods

The present study was undertaken to evaluate the effect of soybean trypsin inhibitor (STI) on the generation of oxygen free radical in pancreas of mice during different growth periods. Mice were divided into three groups and fed with different diets for 1, 2, 3, 4 and 5 weeks separately. The results showed that, MDA content of STI group was increased in the first two weeks, and its maximum appeared in the 3rd week, then it was dropped. Glutathione (GSH) content in serum and pancreas and total anti-oxidative capacity (T-AOC) in serum were dropped in the first two weeks, their minimum appeared in the 3rd week, then they were increased. However, the change of glutathione peroxidase (GSH-Px) in serum and pancreas and T-AOC in pancreas showed opposite trend. The present study indicates that the effect of STI on free radicals level in vivo of mice is relative to growth periods.