The combination of laser-assisted surgery with prp for the treatment of bronj in cancer patienta. a pilot study

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-known potential complication of bisphosphonates therapy and its treatment could reckon on different approaches. Recently, encouraging results for BRONJ were showed from some clinical studies using Er,Cr:YSGG laser-assisted surgery. Platelet-Rich Plasma, a new approach to promote tissue regeneration and healing, may be a promising complementary therapy. The aim of this pilot study is to study the effectiveness, in terms of clinical healing, of a combined treatment for BRONJ in a group of cancer patients. Ten oncological patients with BRONJ were consecutively recruited. All patients performed a CT after 3 months from surgery (T^sub 1^) in order to re-stage of the disease. Successful treatments were considered the complete healing and the radiological improvement. At T^sub 0^ 6/10 patients were stage IB, 2/10 were stage IIA and 2/10 were stage IIB. At T^sub 1^, 3/10 cases showed no clinical and radiological signs of BRONJ relapse; 5/10 cases showed clinical improvement, whereas 2/10 showed no-improvement.