Tumournecrosis factor-[alpha] plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients
Summary Genetic polymorphism studies of cytokines may provide an insight into the understanding of acute kidney injury (AKI) and death in intensive care unit (ICU) patients. The aim of this study was to investigate whether the genetic polymorphisms of -308 GC interleukin (IL)-6 and -1082 G>A IL-1...
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| Veröffentlicht in: | Clinical and experimental immunology 2013-08, Vol.173 (2), p.242 |
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| creator | Dalboni, M A Quinto, B M R Grabulosa, C C Narciso, R Monte, J C Durao, M Rizzo, L Cendoroglo, M Santos, O P Batista, M C |
| description | Summary Genetic polymorphism studies of cytokines may provide an insight into the understanding of acute kidney injury (AKI) and death in intensive care unit (ICU) patients. The aim of this study was to investigate whether the genetic polymorphisms of -308 GC interleukin (IL)-6 and -1082 G>A IL-10 may predispose ICU patients to the development of AKI and/or death. In a prospective nested case-control study, 303 ICU patients and 244 healthy individuals were evaluated. The study group included ICU patients who developed AKI (n=139) and 164 ICU patients without AKI. The GG genotype of TNF-[alpha] (low producer phenotype) was significantly lower in the with AKI than without AKI groups and healthy individuals (55 versus 62 versus 73%, respectively; P=0·01). When genotypes were stratified into four categories of TNF-[alpha]/IL-10 combinations, it was observed that low TNF-[alpha] plus low IL-10 producer phenotypes were more prevalent in patients with AKI, renal replacement therapy and death (P |
| doi_str_mv | 10.1111/cei.12100 |
| format | Article |
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The aim of this study was to investigate whether the genetic polymorphisms of -308 G<A tumour necrosis factor (TNF)-[alpha], -174 G>C interleukin (IL)-6 and -1082 G>A IL-10 may predispose ICU patients to the development of AKI and/or death. In a prospective nested case-control study, 303 ICU patients and 244 healthy individuals were evaluated. The study group included ICU patients who developed AKI (n=139) and 164 ICU patients without AKI. The GG genotype of TNF-[alpha] (low producer phenotype) was significantly lower in the with AKI than without AKI groups and healthy individuals (55 versus 62 versus 73%, respectively; P=0·01). When genotypes were stratified into four categories of TNF-[alpha]/IL-10 combinations, it was observed that low TNF-[alpha] plus low IL-10 producer phenotypes were more prevalent in patients with AKI, renal replacement therapy and death (P<0·05). In logistic regression analysis, low TNF-[alpha] producer plus low IL-10 producer phenotypes remained as independent risk factors for AKI and/or death [odds ratio (OR)=2·37, 95% confidence interval (CI): 1·16-4·84; P=0·02] and for renal replacement therapy (RRT) and/or death (OR=3·82, 95% CI: 1·19-12·23; P=0·02). In this study, the combination of low TNF-[alpha] plus low IL-10 producer phenotypes was an independent risk factor to AKI and/or death and RRT and/or death in critically ill patients. Our results should be validated in a larger prospective study with long-term follow-up to emphasize the combination of these genotypes as potential risk factors to AKI in critically ill patients. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/cei.12100</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><ispartof>Clinical and experimental immunology, 2013-08, Vol.173 (2), p.242</ispartof><rights>Journal Compilation © 2013 British Society for Immunology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Dalboni, M A</creatorcontrib><creatorcontrib>Quinto, B M R</creatorcontrib><creatorcontrib>Grabulosa, C C</creatorcontrib><creatorcontrib>Narciso, R</creatorcontrib><creatorcontrib>Monte, J C</creatorcontrib><creatorcontrib>Durao, M</creatorcontrib><creatorcontrib>Rizzo, L</creatorcontrib><creatorcontrib>Cendoroglo, M</creatorcontrib><creatorcontrib>Santos, O P</creatorcontrib><creatorcontrib>Batista, M C</creatorcontrib><title>Tumournecrosis factor-[alpha] plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients</title><title>Clinical and experimental immunology</title><description>Summary Genetic polymorphism studies of cytokines may provide an insight into the understanding of acute kidney injury (AKI) and death in intensive care unit (ICU) patients. The aim of this study was to investigate whether the genetic polymorphisms of -308 G<A tumour necrosis factor (TNF)-[alpha], -174 G>C interleukin (IL)-6 and -1082 G>A IL-10 may predispose ICU patients to the development of AKI and/or death. In a prospective nested case-control study, 303 ICU patients and 244 healthy individuals were evaluated. The study group included ICU patients who developed AKI (n=139) and 164 ICU patients without AKI. The GG genotype of TNF-[alpha] (low producer phenotype) was significantly lower in the with AKI than without AKI groups and healthy individuals (55 versus 62 versus 73%, respectively; P=0·01). When genotypes were stratified into four categories of TNF-[alpha]/IL-10 combinations, it was observed that low TNF-[alpha] plus low IL-10 producer phenotypes were more prevalent in patients with AKI, renal replacement therapy and death (P<0·05). In logistic regression analysis, low TNF-[alpha] producer plus low IL-10 producer phenotypes remained as independent risk factors for AKI and/or death [odds ratio (OR)=2·37, 95% confidence interval (CI): 1·16-4·84; P=0·02] and for renal replacement therapy (RRT) and/or death (OR=3·82, 95% CI: 1·19-12·23; P=0·02). In this study, the combination of low TNF-[alpha] plus low IL-10 producer phenotypes was an independent risk factor to AKI and/or death and RRT and/or death in critically ill patients. Our results should be validated in a larger prospective study with long-term follow-up to emphasize the combination of these genotypes as potential risk factors to AKI in critically ill patients. 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The aim of this study was to investigate whether the genetic polymorphisms of -308 G<A tumour necrosis factor (TNF)-[alpha], -174 G>C interleukin (IL)-6 and -1082 G>A IL-10 may predispose ICU patients to the development of AKI and/or death. In a prospective nested case-control study, 303 ICU patients and 244 healthy individuals were evaluated. The study group included ICU patients who developed AKI (n=139) and 164 ICU patients without AKI. The GG genotype of TNF-[alpha] (low producer phenotype) was significantly lower in the with AKI than without AKI groups and healthy individuals (55 versus 62 versus 73%, respectively; P=0·01). When genotypes were stratified into four categories of TNF-[alpha]/IL-10 combinations, it was observed that low TNF-[alpha] plus low IL-10 producer phenotypes were more prevalent in patients with AKI, renal replacement therapy and death (P<0·05). In logistic regression analysis, low TNF-[alpha] producer plus low IL-10 producer phenotypes remained as independent risk factors for AKI and/or death [odds ratio (OR)=2·37, 95% confidence interval (CI): 1·16-4·84; P=0·02] and for renal replacement therapy (RRT) and/or death (OR=3·82, 95% CI: 1·19-12·23; P=0·02). In this study, the combination of low TNF-[alpha] plus low IL-10 producer phenotypes was an independent risk factor to AKI and/or death and RRT and/or death in critically ill patients. Our results should be validated in a larger prospective study with long-term follow-up to emphasize the combination of these genotypes as potential risk factors to AKI in critically ill patients. [PUBLICATION ABSTRACT]</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1111/cei.12100</doi></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| title | Tumournecrosis factor-[alpha] plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients |
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